Document Details

Document Type : Thesis 
Document Title :
Effect of saffron (Crocus sativus L.) on the embryonic development of mice liver and ovary
تأثير الزعفران على تكوين الكبد والمبيض في أجنة الفئران البيضاء
 
Subject : biological sciences department 
Document Language : Arabic 
Abstract : Saffron is widely used as a food additive, as an important ingredient of Arabic coffee and as a herbal medicine. The aim of this study was to evaluate the effect of aqueous saffron extract on liver and ovary development in mice fetus. Pregnant mice were divided into three groups of fifteen animals each. Group 1 received 10ml/kg body weight bi distilled water as control, group 2 was treated with 100 mg saffron / kg body weight and group 3 was treated with 2.5 mg saffron / kg body weight. Pregnant mother's weight and morphological differences in the maternal uterus were recorded. Embryos were extracted on day 14, 18 of gestation and day 1 neonates. Whole body weight, whole body length, tail length, half head circumference and eye dimensions of the fetus and neonates were recorded. Congenital malformations of all groups were studied. LPO, GSH and total protein content of liver at day 18 of gestation were measured. Histological structure of embryonic liver and ovary was studied. Treated pregnant mice weight showed a fluctuation during pregnancy compared to controls. Both doses significantly reduced fetal growth parameters compared to controls. Congenital malformations were seen in treated fetuses and neonates such as subcutaneous bleeding and head malformations. Significant decrease in LPO, increase in the GSH and a non significant decrease in the total protein content of 18 day livers of embryos of treated pregnant mice was seen compared to the control group. On the histological and ultra-structural level many deteriorations were seen in the liver of embryos of treated pregnant mice such as dilation and congestion of central and portal veins. Sections of the ovary showed an alteration in primary oocyte formation. It was concluded that oral administration of both doses of saffron to pregnant mice caused fetal intrauterine growth retardation and congenital malformations, deterioration of embryonic liver tissue and alteration in embryonic ovarian tissue. 
Supervisor : Dr. Fatmah M. S. Al-Qudsi 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Added Date : Tuesday, April 23, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
امل سعيد عائضAyedh, Amal SaeedResearcherMaster 

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