Document Details

Document Type : Article In Journal 
Document Title :
HEPATOCELLULAR CARCINOMA AND ANGIOGENIC GROWTH FACTORS IN CASES WITH HCV AND/OR HBsAG COINFECTION’
اورام الكبد السرطانية وعوامل نمو الاوعية الدموية في حالات الاصابة بالكبد الوبائي سي بمفردة او مع بي
 
Subject : HEPATOCELLULAR CARCINOMA AND ANGIOGENIC GROWTH FACTORS IN CASES WITH HCV AND/OR HBsAG COINFECTION’ 
Document Language : English 
Abstract : Angiogenic growth factors are involved in several pathological conditions including solid growth, wound healing and organ regeneration. An Interaction between HCC and viral hepatitis conferred by HCV and HbsAg remain debatable. The aim of the present work is to assess the role of certain angiogenic growth factors in HCC respective to the influence of chronic HCV and HPsAg. To achieve this objective, thirty male with HCC (mean age 52+ 6.8) were subclassjfjed into (hrec groups (G1a b,c). Cases in GIa (n = 9) had chronic HCV and HbsAg, cases in Gib n=l I had HCV; cases in Glc n=lO had HBSAg. Twenty cases were equally classified into those wIth chronic HCV (Gil) and those with HbsAg Gill) and compared to ten nrrnal hcakhy states representing the control group (GIV) ,The results revealed increased levels in GlaSfrGIb>aJc>gft>oIJI relative to the control group (OW) for the assessed angiogenic growth factors: platelet derived endothelial cell growth factor (PDECGF), basic fibrobaist growth factor (bFGF), vascular endothelial growth factor (VEOF), hepatocyte growth factor (HGF) and transforming growth factor alpha (TGF-a), in parallel, a similar pauern of change was presented for the tumor marker alpha fetoprotein (AFP) and liver fUtIon tests. In conclusIon, the Increments in assesses angiogenic growth factors and the tumor marker versus alterations in liver function verified the vii emic Impact influenced by chronic HCV and HbsAg in HCC cases. 
ISSN : 0376-8740 
Journal Name : The Egyptian journal of gastroenterology 
Volume : 7 
Issue Number : 2 
Publishing Year : 1423 AH
2002 AD 
Article Type : Article 
Added Date : Tuesday, February 19, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
خالد عمر سراجabualnaja, khaleed omerResearcherDoctoratekabualnaja@kau.edu.sa

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