Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Correlation of leptin and sex hormones with endocrine changes in healthy Saudi women of different body weights العلاقة بين هرمون اللبتين, هرمون الجنس بتغيرات الغدد في السيدات السعوديات الاصحاء ذات اوزان مختلفة |
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Subject |
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Correlation of leptin and sex hormones with endocrine changes in healthy Saudi women of different body weights |
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Document Language |
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English |
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Abstract |
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Background: A relationship between estrogen and leptin has been
described during the follicular phase of both spontaneous menstrual cycles
and cycles stimulated with exogenous follicle-stimulating hormone
(FSH), which suggest that leptin has either a direct effect on or is regulated
by gonadal steroids in the human ovary. To examine the changes
in plasma leptin levels during the menstrual cycle, we studied the association
between plasma leptin and reproductive hormones in young,
healthy Saudi women.
Subjects and Methods: Sixty-five young women between 19 to 39
years of age, with a normal menstrual cycle, were grouped into 33 overweight
and obese females of BMI >25 kg/m2, and 32 lean females of BMI
<25 kg/m2. Anthropometrics measurements were made at the time of the
collection. Samples were analyzed for leptin, progesterone, estradiol
(E2), FSH, luteinizing hormone (LH), cortisol, and testosterone concentrations.
Results: Overweight and obese women, compared with lean, tended to
have a significantly higher plasma leptin levels (11.38± 4.06 vs. 6.22± 2.87
ng/mL; P=0.05). In overweight and obese subjects, circulating leptin concentrations
showed a direct correlation with BMI (r=0.53; P=0.002), hip
circumference (r=0.32; P=0.005), waist-hip ratio (r=0.37; P=0.042), weight
(r=0.41; P=0.021), and E
2
on day 3 (r=0.35; P=0.048). In all correlation
analyses, leptin levels did not correlate with cortisol or testosterone. In
lean subjects, a bivariate correlation analysis showed that plasma leptin
concentrations were directly correlated to hip circumference (r=0.43;
P=0.012). Moreover, a direct correlation was found with progesterone
on day 10 (r=0.43; P=0.014) and E2 on day 24 (r=0.47; P=0.007).
Conclusion: There is a link between plasma leptin and progesterone
concentrations during the menstrual cycle, and the variation in circulating
estradiol concentrations may have an influence on circulating leptin
in female subjects. |
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ISSN |
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1687-1502 |
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Journal Name |
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the egyption journal of biochemistry |
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Volume |
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2 |
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Issue Number |
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26 |
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Publishing Year |
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1426 AH
2005 AD |
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Article Type |
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Article |
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Added Date |
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Monday, February 4, 2013 |
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Researchers
| خالد عمر ابو النجا | abualnaja, khaled omer | Researcher | Doctorate | kabualnaja@ksa.edu.sa |
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